College football picks, schedule: ATS predictions, odds for the top 25 games today in week 4

With a lot of upheaval and surprises already as we move into week 4 of the 2021 college football season, who knows what’s in store for Saturday. Three straight weeks of unpredictable finishes and top-25 knockdowns set the stage for what should be the remaining three quarters of the season. That action continues on Saturday with a number of high profile clashes across the country.

While there are only two ranked matches on Saturday, both have the potential to make headlines. Coincidentally, the games will both be played at neutral venues with four huge programs entering NFL stadiums for the afternoon. No.12 Notre Dame and No.18 Wisconsin will open today’s meeting at Soldier Field in Chicago, while No.7 Texas A&M and No.16 Arkansas will face off at AT&T Stadium in Dallas.

Overall, 22 of the AP’s Top 25-ranked teams will be in action throughout the day with evening games, including Tennessee visiting Florida’s No.11 and West Virginia making a trip to Oklahoma # 4. To keep an eye on all the action, be sure to check out our User Guide and get your remote ready.

While winning is all that matters for the standings, we do care whether these teams will cover their gaps. Be sure to stick with CBS Sports throughout the day for college football coverage, from the opening kickoff Saturday to the final whistle. Let’s take a look at our expert picks for the fourth full Saturday of the season.

Odds via Caesars Sportsbook | Every hour is

No. 12 Notre-Dame vs. No. 18 Wisconsin

Latest odds:

Wisconsin Badgers -6.5

Noon | Fox, fuboTV (Try for free) – Not only do I think Notre Dame covered the gap on Saturday, but I choose him to win the game. While Notre Dame’s offense has struggled lately, there is enough talent in skill positions to be confident in its ability to bounce back. I don’t have about the same level of faith in the Wisconsin offense right now. We’ve all seen how the Badgers struggled to move the ball against Penn State in their opener of the season, and Notre Dame’s defense is just as strong. The Wisconsin defense will keep the Badgers in the game, but unless they force multiple turnovers and possibly a score, I don’t see how the Wisconsin offense scores enough to win the game. Prediction: Notre-Dame (+5.5) – Tom Fornelli

No.7 Texas A&M vs. No.16 Arkansas

Latest odds:

Texas A&M Aggies -5

3:30 p.m. | CBS,, CBS Sports app I’ll take the Aggies to a good old-fashioned slug party. They’ll be able to slow down Arkansas’ running game enough to force KJ Jefferson into awkward passing situations, and a few major mistakes will dramatically change the outcome. Zach Calzada will continue his development as a passer, especially outside of the game, and lead this Texas A&M team to a fierce victory in Jerry World that covers the line. Prediction: Texas A&M (-5.5) – Barrett Sallee

# 9 Clemson at NC State

Latest odds:

Clemson Tigers -10

3:30 p.m. | ESPN, fuboTV (Try for free) – The Carter-Finley Stadium can be a big advantage on the pitch for the Wolfpack, and I think fans will have an impact on another edition of this series that will be undecided in the fourth quarter. Clemson’s defense will keep him low scoring, and low scoring games favor the underdogs. Prediction: NC State (+10) – Chip Patterson

What college football picks can you confidently make in Week 4, and which Top 25 favorite is the toughest? Visit SportsLine to see which teams will win and cover the spread – all from a proven computer model that has grossed nearly $ 3,000 in profits over the past five+ seasons – and find out.

Tennessee at Florida’s No.11

Latest odds:

Florida Gators U19

19h | ESPN, fuboTV (Try for free) – Yes, it was against Tennessee Tech, but the Volunteers found something in defense that looked fundamentally healthy for the first time. This bodes well against an attack in Florida which will likely use more AoE reading features in the offense. Expect both teams to have difficulty getting on and off the pitch. Florida will win, control the game and their defense will shine once again … but Tennessee will have enough success to cover the 20 points. Prediction: Tennessee (+20) – Barrett Sallee

West Virginia at No. 4 in Oklahoma

Latest odds:

Oklahoma Sooners U17

7:30 p.m. | ABC, fuboTV (Try for free) – Oklahoma faced their two FBS opponents on the same score, and West Virginia is probably the best opponent on the calendar at this point. Granted, the Sooners have the ability to turn on the running game and sideline any Big 12 team, though, we’re unlikely to see that dimension against this West Virginia team. For this reason, expect the score to be even closer than it should. Prediction: West Virginia (+16.5) – Shehan Jeyarajah

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